Alexander So Selected Research

Xanthine Oxidase

1/2018	Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.
4/2014	Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice.
1/2013	Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK.

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Alexander So Research Topics

Disease

32	Inflammation (Inflammations) 01/2021 - 01/2002
17	Gout 01/2021 - 01/2007
15	Osteoarthritis 07/2022 - 05/2002
14	Arthritis (Polyarthritis) 07/2022 - 01/2002
12	Rheumatoid Arthritis 01/2020 - 05/2002
7	Pain (Aches) 01/2021 - 01/2009
6	Gouty Arthritis 10/2015 - 01/2007
5	Hyperuricemia 12/2020 - 01/2008
3	Crystal Arthropathies 10/2022 - 01/2021
3	Joint Diseases (Joint Disease) 01/2020 - 07/2012
3	Atherosclerosis 12/2015 - 06/2010
3	Experimental Arthritis 09/2009 - 01/2002
2	Calcinosis 09/2021 - 01/2021
2	Arthralgia (Joint Pain) 01/2019 - 05/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 12/2015
2	Synovitis 05/2017 - 05/2002
2	Rheumatic Diseases (Rheumatism) 07/2013 - 01/2011
2	Hypertension (High Blood Pressure) 06/2010 - 01/2008
2	Endotoxemia 05/2008 - 01/2008
1	Knee Osteoarthritis 01/2020
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2020
1	Hypertrophy 01/2020
1	Neoplasms (Cancer) 10/2019
1	Carcinogenesis 10/2019
1	Peritonitis 01/2018
1	Spondylarthritis (Spinal Arthritis) 03/2016
1	Axial Spondyloarthritis 03/2016
1	Vascular Calcification 01/2016
1	Fever (Fevers) 01/2016

Drug/Important Bio-Agent (IBA)

18	Uric Acid (Urate)IBA 12/2020 - 01/2007
8	Interleukin-1 (Interleukin 1)IBA 01/2018 - 01/2007
7	calcium phosphateIBA 01/2021 - 02/2011
7	InflammasomesIBA 01/2018 - 02/2010
6	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2021 - 01/2007
5	Calcium PyrophosphateIBA 10/2022 - 07/2012
5	CalciumIBA 09/2021 - 01/2013
5	canakinumab FDA Link 03/2015 - 10/2010
5	AntigensIBA 01/2010 - 05/2002
4	CytokinesIBA 07/2022 - 05/2008
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 01/2013
4	InterleukinsIBA 01/2016 - 07/2011
3	FibrinIBA 07/2022 - 03/2003
3	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 10/2021 - 01/2013
3	AntibodiesIBA 01/2021 - 01/2007
3	Febuxostat FDA Link 11/2019 - 01/2008
3	C-Reactive ProteinIBA 01/2019 - 02/2005
3	Xanthine OxidaseIBA 01/2018 - 01/2013
3	Interleukin-6 (Interleukin 6)IBA 01/2016 - 12/2004
3	Colchicine FDA LinkGeneric 07/2011 - 10/2010
3	Monoclonal AntibodiesIBA 07/2011 - 10/2010
3	Peptide Hydrolases (Proteases)FDA Link 01/2010 - 01/2008
3	Technetium (Technetium 99m)IBA 01/2007 - 05/2002
2	Fibrinogen (Factor I)FDA Link 07/2022 - 01/2008
2	GasotransmittersIBA 09/2021 - 01/2018
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 09/2021 - 01/2018
2	CollagenIBA 01/2020 - 01/2017
2	Xanthine DehydrogenaseIBA 11/2019 - 10/2019
2	Allopurinol (Remid)FDA LinkGeneric 05/2017 - 07/2011
2	Methotrexate (Mexate)FDA LinkGeneric 03/2016 - 01/2014
2	Toll-Like Receptor 4IBA 01/2016 - 07/2005
2	EnzymesIBA 01/2016 - 02/2010
2	NucleotidesIBA 12/2015 - 02/2010
2	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2015 - 07/2014
2	Proteins (Proteins, Gene)FDA Link 10/2015 - 01/2007
2	NLR ProteinsIBA 10/2015 - 02/2010
2	rilonacept FDA Link 03/2015 - 05/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2013 - 05/2008
2	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 03/2011 - 10/2010
2	Thrombin FDA Link 09/2009 - 01/2008
2	Factor VIIa (Activated Factor VII)IBA 01/2008 - 03/2003
2	Thromboplastin (Tissue Factor)IBA 01/2008 - 03/2003
2	Immunoglobulin G (IgG)IBA 01/2007 - 12/2004
2	ZymosanIBA 01/2007 - 01/2005
2	Toll-Like Receptor 2IBA 07/2005 - 01/2005
1	Prednisone (Sone)FDA LinkGeneric 01/2021
1	Triamcinolone (Aristocort)FDA Link 01/2021
1	Sulfides (Thioethers)IBA 01/2020
1	adhesion receptorIBA 01/2020
1	IntegrinsIBA 01/2020
1	3-mercaptopyruvate sulphurtransferaseIBA 01/2020
1	CreatinineIBA 01/2020
1	purineIBA 11/2019
1	Oxidoreductases (Dehydrogenase)IBA 10/2019
1	Durapatite (Hydroxylapatite)IBA 01/2019
1	CystathionineIBA 01/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2018
1	LyasesIBA 01/2018
1	Biological ProductsIBA 01/2018
1	lesinuradIBA 05/2017
1	Metalloproteases (Metalloproteinases)IBA 01/2017
1	salicylhydroxamic acid (SHAM)IBA 01/2017
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2016
1	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2016
1	ApolipoproteinsIBA 01/2016
1	sodium thiosulfate FDA Link 01/2016
1	HDL CholesterolIBA 01/2016

Therapy/Procedure

10	Therapeutics 01/2021 - 01/2007
3	Contraindications 03/2015 - 10/2010
1	Meniscectomy 01/2020
1	Intraperitoneal Injections 01/2018